"دليلك للصحة والنظافة"

Immune system  (part 2)  Dendritic cells (DC) • are phagocytes in tissues that are in contact with the external environment; therefore, they are located mainly in the skin, nose, lungs, stomach, and intestines  • named for their resemblance to neuronal dendrites, as both have many spine-like projections, but dendritic cells are in no way connected to the nervous system  • serve as a link between the bodily tissues and the innate and adaptive immune systems, as they present antigen to T cells, one of the key cell types of the adaptive immune system    CELLS OF INNATE AND ADAPTIVE IMMUNITY  • Lymphoid Lineage                   – Large lymphocytes (large granular lymphocytes)                      • Natural killer (NK) cells (CD16, CD56)                      • Inn...

 Immune system THE IMMUNE SYSTEM • Molecules, cells, tissues and organs which provide non-specific and specific protection against • Microorganisms  • Microbial toxins  • Tumor cells  – Crucial to human survival  ORIGIN OF CELLS OF THE IMMUNE SYSTEM • Derived from common progenitor cell in bone marrow – Pluripotent hematopoietic stem cell  • Progenitor Stem Cells  – Myeloid lineage  • Monocyte/macrophage, dendritic cells, PMN’s, mast cells  • Erythroid : Erythrocytes and Megakaryocytes  – Lymphoid lineage  • Small and large lymphocytes                    Hematopoietic stem cell GATA transcription factors are a family of transcription factors characterized by their ability to bind to the DNA sequence "GATA“  Oct-2 is a octamer transcription factor which is part of the POU family.   POU (pronounced 'pow') is a family of proteins that have well-conserved homeodomains...